Homo sapiens Protein: TXNDC17
Summary
InnateDB Protein IDBP-22375.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNDC17
Protein Name thioredoxin domain containing 17
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000250101
InnateDB Gene IDBG-22371 (TXNDC17)
Protein Structure
UniProt Annotation
Function Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. {ECO:0000269PubMed:14607843, ECO:0000269PubMed:14607844}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14607844}.
Disease Associations
Tissue Specificity Ubiquitously expressed in cell lines. {ECO:0000269PubMed:14607844}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0047134 protein-disulfide reductase activity
Biological Process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR010357 Protein of unknown function DUF953, thioredoxin-like
IPR012336 Thioredoxin-like fold
PFAM PF06110
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRA2
PhosphoSite PhosphoSite-Q9BRA2
TrEMBL I3L0K2
UniProt Splice Variant
Entrez Gene 84817
UniGene Hs.708606
RefSeq NP_116120
HUGO HGNC:28218
OMIM
CCDS CCDS11077
HPRD 11656
IMGT
EMBL AC004706 AJ344101 AK291963 BC006405 CH471108
GenPept AAH06405 BAF84652 CAC51435 EAW90302