InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD81

Summary

InnateDB Protein

IDBP-22459.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD81

Protein Name

CD81 molecule

Synonyms

CVID6; S5.7; TAPA1; TSPAN28;

Species

Homo sapiens

Ensembl Protein

ENSP00000263645

InnateDB Gene

IDBG-22455 (CD81)

Protein Structure

UniProt Annotation

Function

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269PubMed:20237408}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 209 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	209 [view]
Protein-Protein	209 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008104	protein localization
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0043128	positive regulation of 1-phosphatidylinositol 4-kinase activity
GO:0046488	phosphatidylinositol metabolic process
GO:0046718	viral entry into host cell
GO:0046813	receptor-mediated virion attachment to host cell
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome