InnateDB Protein
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IDBP-22593.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IMPAD1
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Protein Name
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inositol monophosphatase domain containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262644
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InnateDB Gene
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IDBG-22591 (IMPAD1)
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Protein Structure
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Function |
May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:18695242}; Single-pass type II membrane protein {ECO:0000269PubMed:18695242}.
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Disease Associations |
Chondrodysplasia with joint dislocations, GPAPP type (CDP-GPAPP) [MIM:614078]: A condition consisting of congenital joint dislocations, chondrodysplasia with short stature, micrognathia and cleft palate, and a distinctive face. {ECO:0000269PubMed:21549340}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008254
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3'-nucleotidase activity
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GO:0008441
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3'(2'),5'-bisphosphate nucleotidase activity
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GO:0008934
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inositol monophosphate 1-phosphatase activity
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GO:0046872
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metal ion binding
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GO:0052832
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inositol monophosphate 3-phosphatase activity
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GO:0052833
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inositol monophosphate 4-phosphatase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000760
Inositol monophosphatase
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PFAM |
PF00459
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PRINTS |
PR00377
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NX62
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PhosphoSite |
PhosphoSite-Q9NX62
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TrEMBL |
A0A024R7W0
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UniProt Splice Variant |
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Entrez Gene |
54928
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UniGene |
Hs.743874
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RefSeq |
NP_060283
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HUGO |
HGNC:26019
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OMIM |
614010
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CCDS |
CCDS6169
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HPRD |
06531
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IMGT |
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EMBL |
AK000428
AY032885
BC017797
BC067814
CH471068
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GenPept |
AAH17797
AAH67814
AAK52336
BAA91158
EAW86789
EAW86791
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