InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XAF1

Summary

InnateDB Protein

IDBP-22621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XAF1

Protein Name

XIAP associated factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354822

InnateDB Gene

IDBG-22619 (XAF1)

Protein Structure

UniProt Annotation

Function

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. {ECO:0000269PubMed:11175744, ECO:0000269PubMed:12029096, ECO:0000269PubMed:16432762, ECO:0000269PubMed:17329253, ECO:0000269PubMed:17613533}.

Subcellular Localization

Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.Isoform 1: Nucleus.Isoform 5: Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). {ECO:0000269PubMed:11175744, ECO:0000269PubMed:16343440, ECO:0000269PubMed:17329253, ECO:0000269PubMed:17570219}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006915	apoptotic process
GO:0019221	cytokine-mediated signaling pathway
GO:0031333	negative regulation of protein complex assembly
GO:0035456	response to interferon-beta
GO:0060337	type I interferon signaling pathway