InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE4D

Summary

InnateDB Protein

IDBP-22665.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4D

Protein Name

phosphodiesterase 4D, cAMP-specific

Synonyms

ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4DN2; STRK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000321739

InnateDB Gene

IDBG-22659 (PDE4D)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269PubMed:15260978, ECO:0000269PubMed:15576036}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:14500724}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells. {ECO:0000250}.

Disease Associations

Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]: A pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems. {ECO:0000269PubMed:22464250, ECO:0000269PubMed:22464252, ECO:0000269PubMed:23033274, ECO:0000269PubMed:23043190}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. {ECO:0000269PubMed:12834813, ECO:0000269PubMed:17244609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0019899	enzyme binding
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0031698	beta-2 adrenergic receptor binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding
GO:0051117	ATPase binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002027	regulation of heart rate
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0010469	regulation of receptor activity
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019933	cAMP-mediated signaling
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0032754	positive regulation of interleukin-5 production
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0045822	negative regulation of heart contraction
GO:0050852	T cell receptor signaling pathway
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028	establishment of endothelial barrier
GO:0071320	cellular response to cAMP
GO:0071872	cellular response to epinephrine stimulus
GO:0071875	adrenergic receptor signaling pathway
GO:0086004	regulation of cardiac muscle cell contraction
GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898	negative regulation of relaxation of cardiac muscle

Cellular Component

GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0034704	calcium channel complex