InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP7A1

Summary

InnateDB Protein

IDBP-22672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP7A1

Protein Name

cytochrome P450, family 7, subfamily A, polypeptide 1

Synonyms

CP7A; CYP7; CYPVII;

Species

Homo sapiens

Ensembl Protein

ENSP00000301645

InnateDB Gene

IDBG-22670 (CYP7A1)

Protein Structure

UniProt Annotation

Function

Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269PubMed:19965590}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Detected in liver. {ECO:0000269PubMed:15796896}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008123	cholesterol 7-alpha-monooxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006805	xenobiotic metabolic process
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0042632	cholesterol homeostasis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070857	regulation of bile acid biosynthetic process
GO:0071333	cellular response to glucose stimulus
GO:0071397	cellular response to cholesterol