Version 5.4
Homo sapiens Protein: TROVE2
Summary
InnateDB Protein IDBP-226963.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TROVE2
Protein Name TROVE domain family, member 2
Synonyms RO60; RORNP; SSA2;
Species Homo sapiens
Ensembl Protein ENSP00000383752
InnateDB Gene IDBG-105471 (TROVE2)
Protein Structure
UniProt Annotation
Function RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. {ECO:0000269PubMed:18056422}.May play roles in cilia formation and/or maintenance. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 29 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006383 transcription from RNA polymerase III promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR008858 TROVE
PFAM PF00092
PF05731
PRINTS
PIRSF
SMART SM00327
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10155
PhosphoSite PhosphoSite-P10155
TrEMBL G5E9R9
UniProt Splice Variant
Entrez Gene 6738
UniGene Hs.597894
RefSeq NP_001166995
HUGO HGNC:11313
OMIM 600063
CCDS CCDS1379
HPRD 15964
IMGT
EMBL AK314594 AL136370 AY205314 AY205315 BC036658 CH471067 J04137 M25077 U44388
GenPept AAA35493 AAA35532 AAB81552 AAB81553 AAH36658 AAO47001 AAO47002 BAG37166 EAW91239 EAW91240 EAW91241 EAW91242 EAW91243 EAW91244 EAW91245 EAW91246 EAW91247

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca