Version 5.4
Homo sapiens Protein: DCK
Summary
InnateDB Protein IDBP-22844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCK
Protein Name deoxycytidine kinase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000286648
InnateDB Gene IDBG-22842 (DCK)
Protein Structure
UniProt Annotation
Function Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. {ECO:0000269PubMed:18377927, ECO:0000269PubMed:20614893}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9342341}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 22 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004137 deoxycytidine kinase activity
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019206 nucleoside kinase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0043097 pyrimidine nucleoside salvage
GO:0043101 purine-containing compound salvage
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR002624 Deoxynucleoside kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01712
PRINTS
PIRSF PIRSF000705
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27707
PhosphoSite PhosphoSite-P27707
TrEMBL F5CTF3
UniProt Splice Variant
Entrez Gene 1633
UniGene Hs.709
RefSeq NP_000779
HUGO HGNC:2704
OMIM 125450
CCDS CCDS3548
HPRD 00507
IMGT
EMBL AK303292 AK313523 BC103764 BC114617 BT019941 BT019942 CH471057 CR536527 CR541876 JF806429 M60527
GenPept AAA35752 AAI03765 AAI14618 AAV38744 AAV38745 AED02503 BAG36303 BAG64367 CAG38764 CAG46674 EAX05637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca