InnateDB Protein
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IDBP-228544.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MACC1
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Protein Name
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metastasis associated in colon cancer 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000383185
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InnateDB Gene
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IDBG-9175 (MACC1)
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Protein Structure
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Function |
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269PubMed:19098908}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:19098908}. Nucleus {ECO:0000269PubMed:19098908}. Note=Mainly found in the cytoplasm in non-metastasizing tumors.
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Disease Associations |
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Tissue Specificity |
Preferentially expressed in metastasizing tumors. {ECO:0000269PubMed:19098908}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008083
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growth factor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011029
Death-like domain
IPR011511
Variant SH3 domain
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PFAM |
PF07653
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZN28
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PhosphoSite |
PhosphoSite-Q6ZN28
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
346389
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UniGene |
Hs.598388
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RefSeq |
NP_877439
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HUGO |
HGNC:30215
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OMIM |
612646
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CCDS |
CCDS5369
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HPRD |
12381
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IMGT |
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EMBL |
AC007001
AJ313524
AK128850
AK131400
BC137090
CH236948
CH471073
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GenPept |
AAI37091
BAC87646
BAD18547
CAC86408
EAL24276
EAW93719
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