Version 5.4
Homo sapiens Protein: NUPR1
Summary
InnateDB Protein IDBP-22856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUPR1
Protein Name nuclear protein, transcriptional regulator, 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315559
InnateDB Gene IDBG-22854 (NUPR1)
Protein Structure
UniProt Annotation
Function Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. {ECO:0000269PubMed:19650074, ECO:0000269PubMed:22565310, ECO:0000269PubMed:22858377}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10092851}.
Disease Associations
Tissue Specificity Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes. {ECO:0000269PubMed:10092851}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016049 cell growth
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR018792 Nuclear phosphoprotein p8, DNA binding
PFAM PF10195
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60356
PhosphoSite PhosphoSite-O60356
TrEMBL A0A024QZC4
UniProt Splice Variant
Entrez Gene 26471
UniGene
RefSeq NP_036517
HUGO HGNC:29990
OMIM 614812
CCDS CCDS10634
HPRD 17814
IMGT
EMBL AC002425 AF069073 AF069074 AF135266 AK312135 BC002434 BM792961 BT006896 CH471279 CR542144
GenPept AAC05335 AAC05336 AAC19384 AAC19385 AAD49221 AAH02434 AAP35542 BAG35071 CAG46941 EAW52274 EAW52276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca