Version 5.4
Homo sapiens Protein: SFI1
Summary
InnateDB Protein IDBP-228600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFI1
Protein Name Sfi1 homolog, spindle assembly associated (yeast)
Synonyms hSfi1p; PISD; PPP1R139;
Species Homo sapiens
Ensembl Protein ENSP00000383145
InnateDB Gene IDBG-4730 (SFI1)
Protein Structure
UniProt Annotation
Function Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. {ECO:0000269PubMed:16956364}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:14504268, ECO:0000269PubMed:16956364}. Note=Localized close to the centriole.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005814 centriole
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR013763 Cyclin-like
PFAM
PRINTS
PIRSF
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A8K8P3
PhosphoSite PhosphoSite-A8K8P3
TrEMBL X6RJF9
UniProt Splice Variant
Entrez Gene 9814
UniGene Hs.679749
RefSeq NP_001007468
HUGO HGNC:29064
OMIM 612765
CCDS CCDS43004
HPRD 11550
IMGT
EMBL AB011114 AK292408 AK293987 AK303362 AL096701 AL096768 AL109802 BC021576 BC110814 BC129926 BC129945
GenPept AAH21576 AAI10815 AAI29927 AAI29946 BAA25468 BAF85097 BAH11642 BAH13949 CAH70755 CAI12881 CAI23034 CAM13202 CAM14700 CAM14701 CAM28334 CAX14857 CAX14858 CAX15240 CAX15241

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca