Homo sapiens Protein: CSNK2A1
InnateDB Protein IDBP-228736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSNK2A1
Protein Name casein kinase 2, alpha 1 polypeptide
Synonyms CK2A1; CKII; CSNK2A3;
Species Homo sapiens
Ensembl Protein ENSP00000383076
InnateDB Gene IDBG-37787 (CSNK2A1)
Protein Structure
UniProt Annotation
Function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin- mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry. {ECO:0000269PubMed:11239457, ECO:0000269PubMed:11704824, ECO:0000269PubMed:16193064, ECO:0000269PubMed:19188443, ECO:0000269PubMed:20625391, ECO:0000269PubMed:22406621}.
Subcellular Localization
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 440 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 440 [view]
Protein-Protein 433 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0047485 protein N-terminus binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0008284 positive regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030307 positive regulation of cell growth
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0048511 rhythmic process
GO:0061077 chaperone-mediated protein folding
GO:0071174 mitotic spindle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0031519 PcG protein complex
Protein Structure and Domains
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002575 Aminoglycoside phosphotransferase
IPR011009 Protein kinase-like domain
PFAM PF00069
Post-translational Modifications
SwissProt P68400
PhosphoSite PhosphoSite-P68400
UniProt Splice Variant
Entrez Gene 1457
UniGene Hs.741126
RefSeq NP_808228
OMIM 115440
HPRD 00277
EMBL AB451279 AK302583 AL049761 BC011668 BC053532 BC071167 BT019792 CH471133 J02853 M55265 S53149 X70251
GenPept AAA35503 AAA56821 AAH11668 AAH53532 AAH71167 AAV38595 ABB72474 BAG63838 BAG70093 CAA49758 CAB65624 EAX10665 EAX10666 EAX10667 EAX10668 EAX10669