Version 5.4
Homo sapiens Protein: GABRA5
Summary
InnateDB Protein IDBP-229073.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRA5
Protein Name gamma-aminobutyric acid (GABA) A receptor, alpha 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382953
InnateDB Gene IDBG-4400 (GABRA5)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005215 transporter activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007165 signal transduction
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005435 Gamma-aminobutyric-acid A receptor, alpha 5 subunit
IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR01079
PR01618
PR01620
PR00253
PR00252
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31644
PhosphoSite PhosphoSite-P31644
TrEMBL G3V408
UniProt Splice Variant
Entrez Gene 2558
UniGene
RefSeq NP_001158509
HUGO HGNC:4079
OMIM 137142
CCDS CCDS45194
HPRD 08840
IMGT
EMBL AC127511 AC135999 AC145167 AC145196 AF061785 AF228447 AF228448 AF228449 AK290453 AK303742 BC111979 BC113422 BT009830 CH471151 EU606048 L08485
GenPept AAA58490 AAC31809 AAF62508 AAF62509 AAF62510 AAI11980 AAI13423 AAP88832 BAF83142 BAG64714 EAW57656 EAW57657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca