InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC4A7

Summary

InnateDB Protein

IDBP-22925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC4A7

Protein Name

solute carrier family 4, sodium bicarbonate cotransporter, member 7

Synonyms

NBC2; NBC3; NBCN1; SBC2; SLC4A6;

Species

Homo sapiens

Ensembl Protein

ENSP00000295736

InnateDB Gene

IDBG-22923 (SLC4A7)

Protein Structure

UniProt Annotation

Function

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. {ECO:0000269PubMed:10347222, ECO:0000269PubMed:12403779}.

Subcellular Localization

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}. Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle. {ECO:0000269PubMed:9610397}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0008509	anion transmembrane transporter activity
GO:0008510	sodium:bicarbonate symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006820	anion transport
GO:0015701	bicarbonate transport
GO:0021747	cochlear nucleus development
GO:0035725	sodium ion transmembrane transport
GO:0046666	retinal cell programmed cell death
GO:0055085	transmembrane transport
GO:0060117	auditory receptor cell development
GO:0061299	retina vasculature morphogenesis in camera-type eye

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0032420	stereocilium

Protein Structure and Domains

PDB ID

InterPro

IPR003020 Bicarbonate transporter, eukaryotic
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter

PFAM

PF00955
PF07565

PRINTS

PR01231

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y6M7