Version 5.4
Homo sapiens Protein: RNASE9
Summary
InnateDB Protein IDBP-2293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE9
Protein Name ribonuclease, RNase A family, 9 (non-active)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340162
InnateDB Gene IDBG-2291 (RNASE9)
Protein Structure
UniProt Annotation
Function Does not exhibit any ribonuclease activity. {ECO:0000269PubMed:18992174, ECO:0000269PubMed:19137000}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity At the mRNA level, widely expressed (PubMed:18992174). At protein level, restricted to epididymis (PubMed:19137000). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle. {ECO:0000269PubMed:18992174, ECO:0000269PubMed:19137000}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
Biological Process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR023412 Ribonuclease A-domain
PFAM PF00074
PRINTS
PIRSF
SMART SM00092
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P60153
PhosphoSite PhosphoSite-
TrEMBL W0UV99
UniProt Splice Variant
Entrez Gene 390443
UniGene Hs.533972
RefSeq NP_001001673
HUGO HGNC:20673
OMIM 614014
CCDS CCDS32036
HPRD 17983
IMGT
EMBL AF382949 AL163195 AY665804 AY907670 BC130311 BC130313 EF061296 EF061297 EF061298 EF061299 EF061300 EF061301 EF061302 EF061303 EF061304 EU414264 HG328847
GenPept AAI30312 AAI30314 AAQ02792 AAV87182 AAX86045 ABP97451 ABP97452 ABP97453 ABP97454 ABP97455 ABP97456 ABP97457 ABP97458 ABP97459 ACA49544 CDG31923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca