InnateDB Protein
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IDBP-229515.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEH1L
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Protein Name
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SEH1-like (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000382779
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InnateDB Gene
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IDBG-1204 (SEH1L)
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Protein Structure
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Function |
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway. {ECO:0000269PubMed:15146057, ECO:0000269PubMed:17363900, ECO:0000269PubMed:23723238}.
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Subcellular Localization |
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR020472
G-protein beta WD-40 repeat
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PFAM |
PF00400
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PRINTS |
PR00320
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q96EE3
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PhosphoSite |
PhosphoSite-Q96EE3
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TrEMBL |
K7EPZ5
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UniProt Splice Variant |
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Entrez Gene |
81929
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UniGene |
Hs.731967
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RefSeq |
NP_001013455
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HUGO |
HGNC:30379
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OMIM |
609263
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CCDS |
CCDS32791
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HPRD |
15319
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IMGT |
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EMBL |
AF136976
AF255625
AF431970
AF514996
AK056940
AK291226
AP002449
BC012430
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GenPept |
AAG49437
AAH12430
AAM21169
AAM44214
AAM76707
BAB71317
BAF83915
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