InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GYS2

Summary

InnateDB Protein

IDBP-22958.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GYS2

Protein Name

glycogen synthase 2 (liver)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261195

InnateDB Gene

IDBG-22956 (GYS2)

Protein Structure

UniProt Annotation

Function

Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.

Subcellular Localization

Disease Associations

Glycogen storage disease 0 (GSD0) [MIM:240600]: A metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood, high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia. {ECO:0000269PubMed:9691087}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004373	glycogen (starch) synthase activity
GO:0042803	protein homodimerization activity
GO:0061547	glycogen synthase activity, transferring glucose-1-phosphate

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006006	glucose metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0009058	biosynthetic process
GO:0009749	response to glucose
GO:0044281	small molecule metabolic process