InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFITM3

Summary

InnateDB Protein

IDBP-229735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFITM3

Protein Name

interferon induced transmembrane protein 3

Synonyms

1-8U; DSPA2b; IP15;

Species

Homo sapiens

Ensembl Protein

ENSP00000382707

InnateDB Gene

IDBG-16268 (IFITM3)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. {ECO:0000269PubMed:20064371, ECO:0000269PubMed:20534863, ECO:0000269PubMed:20943977, ECO:0000269PubMed:21177806, ECO:0000269PubMed:21253575, ECO:0000269PubMed:22046135, ECO:0000269PubMed:22479637, ECO:0000269PubMed:23601107}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	7 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0009607	response to biotic stimulus
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0032897	negative regulation of viral transcription
GO:0034341	response to interferon-gamma
GO:0035455	response to interferon-alpha
GO:0035456	response to interferon-beta
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome