InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP47

Summary

InnateDB Protein

IDBP-230578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP47

Protein Name

ubiquitin specific peptidase 47

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000382382

InnateDB Gene

IDBG-32135 (USP47)

Protein Structure

UniProt Annotation

Function

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. {ECO:0000269PubMed:19966869, ECO:0000269PubMed:21362556}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21362556}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, heart and testis. {ECO:0000269PubMed:14715245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0071987	WD40-repeat domain binding

Biological Process

GO:0006284	base-excision repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006974	cellular response to DNA damage stimulus
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle
GO:0030307	positive regulation of cell growth
GO:0034644	cellular response to UV
GO:0035520	monoubiquitinated protein deubiquitination
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005737	cytoplasm
GO:0019005	SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00443

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96K76

PhosphoSite