InnateDB Protein
|
IDBP-233188.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
STXBP4
|
Protein Name
|
syntaxin binding protein 4
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000381427
|
InnateDB Gene
|
IDBG-59961 (STXBP4)
|
Protein Structure
|
|
Function |
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
7
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006974
|
cellular response to DNA damage stimulus
|
GO:0010838
|
positive regulation of keratinocyte proliferation
|
GO:0050821
|
protein stabilization
|
GO:1902808
|
positive regulation of cell cycle G1/S phase transition
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6ZWJ1
|
PhosphoSite |
PhosphoSite-Q6ZWJ1
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
252983
|
UniGene |
Hs.604855
|
RefSeq |
|
HUGO |
HGNC:19694
|
OMIM |
610415
|
CCDS |
|
HPRD |
18127
|
IMGT |
|
EMBL |
AC005177
AC007485
AK122865
BC041485
|
GenPept |
AAH41485
BAC85511
|
|
|