InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DIMT1

Summary

InnateDB Protein

IDBP-23323.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIMT1

Protein Name

DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000199320

InnateDB Gene

IDBG-23321 (DIMT1)

Protein Structure

UniProt Annotation

Function

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0008649	rRNA methyltransferase activity
GO:0016433	rRNA (adenine) methyltransferase activity
GO:0044822	poly(A) RNA binding
GO:0052909	18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity

Biological Process

GO:0000154	rRNA modification
GO:0006364	rRNA processing
GO:0031167	rRNA methylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001737 Ribosomal RNA adenine methylase transferase
IPR011530 Ribosomal RNA adenine dimethylase
IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00398

PRINTS

PIRSF

SMART

SM00650

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UNQ2