Version 5.4
Homo sapiens Protein: TMEM123
Summary
InnateDB Protein IDBP-233811.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM123
Protein Name transmembrane protein 123
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381204
InnateDB Gene IDBG-69084 (TMEM123)
Protein Structure
UniProt Annotation
Function Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. {ECO:0000269PubMed:11481458}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Not expressed in ovary. Expressed in keratinocytes. {ECO:0000269PubMed:11481458, ECO:0000269PubMed:12752121}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
Biological Process
GO:0070267 oncosis
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N131
PhosphoSite PhosphoSite-Q8N131
TrEMBL E9PKT4
UniProt Splice Variant
Entrez Gene 114908
UniGene Hs.742016
RefSeq NP_443164
HUGO HGNC:30138
OMIM 606356
CCDS CCDS41702
HPRD
IMGT
EMBL AK075420 AP000942 AP001830 AY008283 AY157580 AY358696 BC032296
GenPept AAG21694 AAH32296 AAO13164 AAQ89059 BAC11610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca