InnateDB Protein
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IDBP-233943.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGPAT3
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Protein Name
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1-acylglycerol-3-phosphate O-acyltransferase 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381140
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InnateDB Gene
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IDBG-4929 (AGPAT3)
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Protein Structure
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Function |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. {ECO:0000269PubMed:21173190}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver. {ECO:0000269PubMed:21173190}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003841
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1-acylglycerol-3-phosphate O-acyltransferase activity
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GO:0016746
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transferase activity, transferring acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002123
Phospholipid/glycerol acyltransferase
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PFAM |
PF01553
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PRINTS |
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PIRSF |
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SMART |
SM00563
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NRZ7
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PhosphoSite |
PhosphoSite-Q9NRZ7
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TrEMBL |
C9JQX8
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UniProt Splice Variant |
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Entrez Gene |
56894
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UniGene |
Hs.738662
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RefSeq |
NP_001032642
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HUGO |
HGNC:326
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OMIM |
614794
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CCDS |
CCDS13703
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HPRD |
10637
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IMGT |
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EMBL |
AB040138
AF156774
AF156775
AK125804
AL832919
AP001053
AP001054
AY358704
BC011971
BC040603
BC063552
CH471079
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GenPept |
AAF80336
AAF80337
AAH11971
AAH40603
AAH63552
AAQ89067
BAB18943
BAC86299
CAD38635
EAX09461
EAX09463
EAX09464
EAX09465
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