InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSGALNACT1

Summary

InnateDB Protein

IDBP-234105.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSGALNACT1

Protein Name

chondroitin sulfate N-acetylgalactosaminyltransferase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000381084

InnateDB Gene

IDBG-9548 (CSGALNACT1)

Protein Structure

UniProt Annotation

Function

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. {ECO:0000269PubMed:11788602, ECO:0000269PubMed:12163485, ECO:0000269PubMed:12446672, ECO:0000269PubMed:17145758}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000305PubMed:11788602}; Single-pass type II membrane protein {ECO:0000305PubMed:11788602}.

Disease Associations

Tissue Specificity

Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined. {ECO:0000269PubMed:11788602, ECO:0000269PubMed:12163485, ECO:0000269PubMed:12446672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008376	acetylgalactosaminyltransferase activity
GO:0008955	peptidoglycan glycosyltransferase activity
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0046872	metal ion binding
GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007399	nervous system development
GO:0008037	cell recognition
GO:0008283	cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0019276	UDP-N-acetylgalactosamine metabolic process
GO:0030166	proteoglycan biosynthetic process
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030210	heparin biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046398	UDP-glucuronate metabolic process
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
GO:0050651	dermatan sulfate proteoglycan biosynthetic process
GO:0050653	chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process