InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FRS2

Summary

InnateDB Protein

IDBP-234116.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FRS2

Protein Name

fibroblast growth factor receptor substrate 2

Synonyms

FRS2A; FRS2alpha; SNT; SNT-1; SNT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000381083

InnateDB Gene

IDBG-47144 (FRS2)

Protein Structure

UniProt Annotation

Function

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269PubMed:12974390, ECO:0000269PubMed:21765395}.

Subcellular Localization

Endomembrane system. Note=Cytoplasmic, membrane-bound.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:10092678}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104	fibroblast growth factor receptor binding
GO:0005158	insulin receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0019211	phosphatase activator activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling