Version 5.4
Homo sapiens Protein: INTS10
Summary
InnateDB Protein IDBP-234128.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS10
Protein Name integrator complex subunit 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381064
InnateDB Gene IDBG-9603 (INTS10)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Subcellular Localization Nucleus {ECO:0000269PubMed:16239144}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NVR2
PhosphoSite PhosphoSite-Q9NVR2
TrEMBL E5RJN5
UniProt Splice Variant
Entrez Gene 55174
UniGene Hs.512627
RefSeq NP_060612
HUGO HGNC:25548
OMIM 611353
CCDS CCDS6011
HPRD 07686
IMGT
EMBL AC107964 AK001431 AL442078 BC001915 BC006209 BC051282 BK005727 CR457262
GenPept AAH01915 AAH06209 AAH51282 BAA91687 CAC09444 CAG33543 DAA05727

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca