InnateDB Protein
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IDBP-2345.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANG
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Protein Name
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angiogenin, ribonuclease, RNase A family, 5
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Synonyms
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ALS9; HEL168; RAA1; RNASE4; RNASE5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000336762
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InnateDB Gene
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IDBG-234136 (ANG)
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Protein Structure
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Function |
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269PubMed:12051708, ECO:0000269PubMed:1400510, ECO:0000269PubMed:19354288, ECO:0000269PubMed:21855800}.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
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Disease Associations |
Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. {ECO:0000269PubMed:15557516, ECO:0000269PubMed:16501576, ECO:0000269PubMed:17703939, ECO:0000269PubMed:17886298, ECO:0000269PubMed:18087731}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269PubMed:17886298, ECO:0000269PubMed:2440105}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001427
Pancreatic ribonuclease
IPR023412
Ribonuclease A-domain
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PFAM |
PF00074
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PRINTS |
PR00794
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PIRSF |
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SMART |
SM00092
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TIGRFAMs |
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Modification |
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SwissProt |
P03950
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PhosphoSite |
PhosphoSite-P03950
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TrEMBL |
W0UV28
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UniProt Splice Variant |
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Entrez Gene |
283
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UniGene |
Hs.743472
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RefSeq |
NP_001136
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HUGO |
HGNC:483
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OMIM |
105850
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CCDS |
CCDS9554
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HPRD |
00105
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IMGT |
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EMBL |
AF449647
AF449648
AF449649
AF449650
AF449651
AK313989
BC020704
BC054880
BC062698
CH471078
CR407633
FJ236304
HG328835
M11567
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GenPept |
AAA51678
AAH20704
AAH54880
AAH62698
AAL67710
AAL67711
AAL67712
AAL67713
AAL67714
ACI45236
BAG36701
CAG28561
CDG31911
EAW66450
EAW66451
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