Homo sapiens Protein: NFATC1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-234560.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | NFATC1 | ||||||||||||||||||||||
Protein Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | ||||||||||||||||||||||
Synonyms | NF-ATC; NFAT2; NFATc; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000380892 | ||||||||||||||||||||||
InnateDB Gene | IDBG-5452 (NFATC1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:16511445}. Nucleus {ECO:0000269PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. {ECO:0000269PubMed:18675896}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR002909
IPT domain IPR008366 Nuclear factor of activated T cells (NFAT) IPR008967 p53-like transcription factor, DNA-binding IPR011539 Rel homology domain IPR014756 Immunoglobulin E-set |
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PFAM |
PF01833
PF00554 |
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PRINTS |
PR01789
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PIRSF | |||||||||||||||||||||||
SMART |
SM00429
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O95644 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O95644 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 4772 | ||||||||||||||||||||||
UniGene | Hs.739976 | ||||||||||||||||||||||
RefSeq | NP_765976 | ||||||||||||||||||||||
HUGO | HGNC:7775 | ||||||||||||||||||||||
OMIM | 600489 | ||||||||||||||||||||||
CCDS | CCDS12016 | ||||||||||||||||||||||
HPRD | 02729 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC018445 AC023090 BC104753 BC112243 CH471117 EU887559 EU887560 EU887561 EU887562 EU887563 EU887564 EU887565 EU887566 U08015 U59736 U80917 U80918 U80919 | ||||||||||||||||||||||
GenPept | AAA19601 AAC50869 AAD00450 AAD00451 AAD00452 AAI04754 AAI12244 ACG55579 ACG55580 ACG55581 ACG55582 ACG55583 ACG55584 ACG55585 ACG55586 EAW66621 EAW66622 | ||||||||||||||||||||||