InnateDB Protein
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IDBP-234933.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIGIRR
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Protein Name
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single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380756
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InnateDB Gene
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IDBG-16551 (SIGIRR)
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Protein Structure
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Function |
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269PubMed:12925853, ECO:0000269PubMed:14715412, ECO:0000269PubMed:15866876}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269PubMed:14715412, ECO:0000269PubMed:21077278}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001960
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negative regulation of cytokine-mediated signaling pathway
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GO:0006953
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acute-phase response
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GO:0007165
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signal transduction
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GO:0031665
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negative regulation of lipopolysaccharide-mediated signaling pathway
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GO:0043433
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negative regulation of sequence-specific DNA binding transcription factor activity
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GO:0045079
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negative regulation of chemokine biosynthetic process
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GO:0045087
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innate immune response (InnateDB)
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Cellular Component |
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PDB ID |
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InterPro |
IPR000157
Toll/interleukin-1 receptor homology (TIR) domain
IPR007110
Immunoglobulin-like domain
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PFAM |
PF01582
PF13676
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PRINTS |
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PIRSF |
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SMART |
SM00255
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TIGRFAMs |
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Modification |
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SwissProt |
Q6IA17
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PhosphoSite |
PhosphoSite-Q6IA17
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
59307
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UniGene |
Hs.501624
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RefSeq |
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HUGO |
HGNC:30575
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OMIM |
605478
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CCDS |
CCDS31325
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HPRD |
12018
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IMGT |
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EMBL |
AC138230
AK025099
AY358342
BC003591
BC025953
BC106007
CR457338
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GenPept |
AAH03591
AAH25953
AAI06008
AAQ88708
BAB15066
CAG33619
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