Homo sapiens Protein: STK24 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-235195.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | STK24 | ||||||||||||||||||||||
Protein Name | serine/threonine kinase 24 | ||||||||||||||||||||||
Synonyms | HEL-S-95; MST3; MST3B; STE20; STK3; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000380651 | ||||||||||||||||||||||
InnateDB Gene | IDBG-44849 (STK24) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269PubMed:16314523, ECO:0000269PubMed:17046825, ECO:0000269PubMed:19604147, ECO:0000269PubMed:19782762, ECO:0000269PubMed:19855390}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9Y6E0 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9Y6E0 | ||||||||||||||||||||||
TrEMBL | Q5JV99 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8428 | ||||||||||||||||||||||
UniGene | Hs.713712 | ||||||||||||||||||||||
RefSeq | NP_001273578 | ||||||||||||||||||||||
HUGO | HGNC:11403 | ||||||||||||||||||||||
OMIM | 604984 | ||||||||||||||||||||||
CCDS | CCDS66573 | ||||||||||||||||||||||
HPRD | 10385 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF024636 AF083420 AK299140 AL137249 AL356423 BC035578 CH471085 | ||||||||||||||||||||||
GenPept | AAB82560 AAD42039 AAH35578 BAG61192 CAI13114 CAI39453 EAX08986 | ||||||||||||||||||||||