InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRMT5

Summary

InnateDB Protein

IDBP-235307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT5

Protein Name

protein arginine methyltransferase 5

Synonyms

HRMT1L5; IBP72; JBP1; SKB1; SKB1Hs;

Species

Homo sapiens

Ensembl Protein

ENSP00000380582

InnateDB Gene

IDBG-2920 (PRMT5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 217 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	217 [view]
Protein-Protein	211 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0007088	regulation of mitosis
GO:0008283	cell proliferation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0018216	peptidyl-arginine methylation
GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0032922	circadian regulation of gene expression
GO:0034660	ncRNA metabolic process
GO:0035246	peptidyl-arginine N-methylation
GO:0042118	endothelial cell activation
GO:0043985	histone H4-R3 methylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034709	methylosome

Protein Structure and Domains

PDB ID

InterPro

IPR007857 Protein arginine N-methyltransferase PRMT5
IPR025799 Protein arginine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF05185

PRINTS

PIRSF

PIRSF015894

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14744