Version 5.4
Homo sapiens Protein: HMBOX1
Summary
InnateDB Protein IDBP-235547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMBOX1
Protein Name homeobox containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380516
InnateDB Gene IDBG-15380 (HMBOX1)
Protein Structure
UniProt Annotation
Function Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor. {ECO:0000269PubMed:16825764, ECO:0000269PubMed:19757162}.
Subcellular Localization Nucleus. Cytoplasm. Note=Predominantly detected in cytoplasm.
Disease Associations
Tissue Specificity Ubiquitous. Detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart, bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, and colon. {ECO:0000269PubMed:16825764, ECO:0000269PubMed:19757162}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR006899 Hepatocyte nuclear factor 1, N-terminal
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
PFAM PF00046
PF04814
PF13413
PRINTS
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NT76
PhosphoSite PhosphoSite-Q6NT76
TrEMBL H0YBM8
UniProt Splice Variant
Entrez Gene 79618
UniGene Hs.609468
RefSeq NP_078843
HUGO HGNC:26137
OMIM
CCDS CCDS6071
HPRD 07964
IMGT
EMBL AC040975 AC091558 AC108449 AK025269 AK290683 AK295320 AY522342 BC009259 BC069242 CH471080 DQ153248 DQ269478
GenPept AAH09259 AAH69242 AAS76643 AAZ81565 ABB82947 BAB15099 BAF83372 BAG58297 EAW63496 EAW63499 EAW63500

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca