InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HAGH

Summary

InnateDB Protein

IDBP-235557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAGH

Protein Name

hydroxyacylglutathione hydrolase

Synonyms

GLO2; GLX2; GLXII; HAGH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000380514

InnateDB Gene

IDBG-9334 (HAGH)

Protein Structure

UniProt Annotation

Function

Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid.

Subcellular Localization

Isoform 1: Mitochondrion matrix.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in liver and kidney. {ECO:0000269PubMed:15117945}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004416	hydroxyacylglutathione hydrolase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006750	glutathione biosynthetic process
GO:0008152	metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001279 Beta-lactamase-like
IPR017782 Hydroxyacylglutathione hydrolase

PFAM

PF00753

PRINTS

PIRSF

PIRSF005457

SMART

SM00849

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16775

PhosphoSite

PhosphoSite-Q16775

TrEMBL

H3BV79

UniProt Splice Variant

Entrez Gene

3029

UniGene

Hs.157394

RefSeq

NP_005317

HUGO

HGNC:4805

OMIM

138760

CCDS

CCDS10447

HPRD

00731

IMGT

EMBL

AC012180 AE006639 AK290155 AK298174 AK299173 AK299993 BC000840 BC002627 X90999

GenPept

AAH00840 AAH02627 AAK61294 BAF82844 BAG60445 BAG61219 BAG61813 CAA62483