InnateDB Protein
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IDBP-235767.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL15RA
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Protein Name
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interleukin 15 receptor, alpha
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Synonyms
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CD215;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380421
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InnateDB Gene
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IDBG-50371 (IL15RA)
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Protein Structure
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Function |
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. {ECO:0000269PubMed:11714793, ECO:0000269PubMed:8530383}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269PubMed:10480910}. Nucleus membrane {ECO:0000269PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269PubMed:10480910}. Note=Mainly found associated with the nuclear membrane.Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space.
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Disease Associations |
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Tissue Specificity |
Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. {ECO:0000269PubMed:10480910, ECO:0000269PubMed:12114302, ECO:0000269PubMed:8530383}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000436
Sushi/SCR/CCP
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PFAM |
PF00084
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
Q13261
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PhosphoSite |
PhosphoSite-
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TrEMBL |
G8CVM3
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UniProt Splice Variant |
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Entrez Gene |
3601
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UniGene |
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RefSeq |
NP_001243694
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HUGO |
HGNC:5978
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OMIM |
601070
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CCDS |
CCDS73065
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HPRD |
03045
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IMGT |
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EMBL |
AF035279
AK304211
AL137186
AY316538
BC074726
BC121140
BC121141
CH471072
CR457064
CR542023
HQ401283
U31628
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GenPept |
AAB88175
AAC50312
AAH74726
AAI21141
AAI21142
AAP69528
AEP26933
BAG65084
CAG33345
CAG46820
CAI41080
CAI41082
CAI41083
EAW86417
EAW86418
EAW86419
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