InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGAP3

Summary

InnateDB Protein

IDBP-235777.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGAP3

Protein Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380413

InnateDB Gene

IDBG-49238 (AGAP3)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269PubMed:16461359, ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16461359}. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15381706, ECO:0000269PubMed:16461359}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032312	regulation of ARF GTPase activity
GO:0034614	cellular response to reactive oxygen species
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR001164 Arf GTPase activating protein
IPR001806 Small GTPase superfamily
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR003579 Small GTPase superfamily, Rab type
IPR013684 Mitochondrial Rho-like
IPR020683 Ankyrin repeat-containing domain
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM