InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCF4

Summary

InnateDB Protein

IDBP-235973.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCF4

Protein Name

neutrophil cytosolic factor 4, 40kDa

Synonyms

NCF; P40PHOX; SH3PXD4;

Species

Homo sapiens

Ensembl Protein

ENSP00000380334

InnateDB Gene

IDBG-6112 (NCF4)

Protein Structure

UniProt Annotation

Function

Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. {ECO:0000269PubMed:8280052}.

Subcellular Localization

Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein.

Disease Associations

Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive (CGD3) [MIM:613960]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. {ECO:0000269PubMed:19692703}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expression is restricted to hematopoietic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0035091	phosphatidylinositol binding
GO:0046983	protein dimerization activity

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006955	immune response
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043085	positive regulation of catalytic activity
GO:0051701	interaction with host
GO:0055114	oxidation-reduction process
GO:0090382	phagosome maturation