InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP1G2

Summary

InnateDB Protein

IDBP-236006.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP1G2

Protein Name

adaptor-related protein complex 1, gamma 2 subunit

Synonyms

G2AD;

Species

Homo sapiens

Ensembl Protein

ENSP00000380309

InnateDB Gene

IDBG-236004 (AP1G2)

Protein Structure

UniProt Annotation

Function

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). {ECO:0000269PubMed:16867982, ECO:0000269PubMed:17553870, ECO:0000269PubMed:9733768}.

Subcellular Localization

Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures. Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures.

Disease Associations

Tissue Specificity

Expressed in all but one (skeletal muscle) tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005798	Golgi-associated vesicle
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030121	AP-1 adaptor complex
GO:0030131	clathrin adaptor complex
GO:0030133	transport vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR008153 Clathrin adaptor, gamma-adaptin, appendage
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR016024 Armadillo-type fold
IPR017107 Adaptor protein complex AP-1, gamma subunit

PFAM

PF01602
PF02883

PRINTS

PIRSF

PIRSF037094

SMART

SM00809

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt