InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAPGEF4

Summary

InnateDB Protein

IDBP-236099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF4

Protein Name

Rap guanine nucleotide exchange factor (GEF) 4

Synonyms

2; CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496;

Species

Homo sapiens

Ensembl Protein

ENSP00000380271

InnateDB Gene

IDBG-75192 (RAPGEF4)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0017016	Ras GTPase binding
GO:0030552	cAMP binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0017156	calcium ion-dependent exocytosis
GO:0017157	regulation of exocytosis
GO:0019933	cAMP-mediated signaling
GO:0030073	insulin secretion
GO:0030168	platelet activation
GO:0032318	regulation of Ras GTPase activity
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0044281	small molecule metabolic process
GO:0045859	regulation of protein kinase activity
GO:0050796	regulation of insulin secretion
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005952	cAMP-dependent protein kinase complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000591 DEP domain
IPR000595 Cyclic nucleotide-binding domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR018490 Cyclic nucleotide-binding-like
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00610
PF00027
PF00618
PF00617

PRINTS

PR00103

PIRSF

SMART

SM00314
SM00049
SM00100
SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt