InnateDB Protein
|
IDBP-236148.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
UPF2
|
Protein Name
|
UPF2 regulator of nonsense transcripts homolog (yeast)
|
Synonyms
|
HUPF2; RENT2; smg-3;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000380244
|
InnateDB Gene
|
IDBG-53271 (UPF2)
|
Protein Structure
|
|
Function |
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. {ECO:0000269PubMed:11163187, ECO:0000269PubMed:16209946, ECO:0000269PubMed:18066079}.
|
Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000269PubMed:11073994, ECO:0000269PubMed:11113196, ECO:0000269PubMed:11163187}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:11073994}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
111
[view]
|
Protein-Protein |
111
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003890
MIF4G-like, type 3
IPR007193
Up-frameshift suppressor 2
IPR016024
Armadillo-type fold
|
PFAM |
PF02854
PF04050
|
PRINTS |
|
PIRSF |
|
SMART |
SM00543
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9HAU5
|
PhosphoSite |
PhosphoSite-Q9HAU5
|
TrEMBL |
B4DHP3
|
UniProt Splice Variant |
|
Entrez Gene |
26019
|
UniGene |
Hs.732383
|
RefSeq |
NP_542166
|
HUGO |
HGNC:17854
|
OMIM |
605529
|
CCDS |
CCDS7086
|
HPRD |
10405
|
IMGT |
|
EMBL |
AB037829
AC073160
AF301013
AF318574
AK000764
AK096191
AK295209
AL080198
AL138898
AL645617
AY013249
BC114964
BC115737
CH471072
|
GenPept |
AAG33225
AAG48509
AAG60689
AAI14965
AAI15738
BAA91369
BAA92646
BAC04721
BAG58205
CAB45771
CAH73458
CAH73459
CAI16755
CAI16756
EAW86329
EAW86330
EAW86332
EAW86333
|
|
|