InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFE2L2

Summary

InnateDB Protein

IDBP-236191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFE2L2

Protein Name

nuclear factor (erythroid-derived 2)-like 2

Synonyms

NRF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000380252

InnateDB Gene

IDBG-75863 (NFE2L2)

Protein Structure

UniProt Annotation

Function

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. {ECO:0000269PubMed:11035812}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

Disease Associations

Tissue Specificity

Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	82 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001221	transcription cofactor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0016567	protein ubiquitination
GO:0030194	positive regulation of blood coagulation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034599	cellular response to oxidative stress
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045995	regulation of embryonic development
GO:0060548	negative regulation of cell death
GO:0070301	cellular response to hydrogen peroxide
GO:0071356	cellular response to tumor necrosis factor
GO:0071499	cellular response to laminar fluid shear stress
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000121	regulation of removal of superoxide radicals
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2000379	positive regulation of reactive oxygen species metabolic process