InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPARG

Summary

InnateDB Protein

IDBP-236265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARG

Protein Name

peroxisome proliferator-activated receptor gamma

Synonyms

CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma;

Species

Homo sapiens

Ensembl Protein

ENSP00000380221

InnateDB Gene

IDBG-18954 (PPARG)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	131 [view]
Protein-DNA	17 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003077 Peroxisome proliferator-activated receptor, gamma
IPR008946 Nuclear hormone receptor, ligand-binding
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal

PFAM

PF00104
PF00105
PF12577

PRINTS

PR00047
PR00398
PR01288
PR01291

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt