InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2G1

Summary

InnateDB Protein

IDBP-236360.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2G1

Protein Name

ubiquitin-conjugating enzyme E2G 1

Synonyms

E217K; UBC7; UBE2G;

Species

Homo sapiens

Ensembl Protein

ENSP00000380178

InnateDB Gene

IDBG-18727 (UBE2G1)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. {ECO:0000269PubMed:19103148, ECO:0000269PubMed:20061386}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed, mainly in skeletal muscle. {ECO:0000269PubMed:8893823}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008152	metabolic process
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination