InnateDB Protein
|
IDBP-23753.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
LRMP
|
Protein Name
|
lymphoid-restricted membrane protein
|
Synonyms
|
JAW1;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000346442
|
InnateDB Gene
|
IDBG-23751 (LRMP)
|
Protein Structure
|
|
Function |
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.
|
Subcellular Localization |
Processed lymphoid-restricted membrane protein: Cytoplasm {ECO:0000250}.Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Chromosome {ECO:0000250}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles. {ECO:0000269PubMed:16739114, ECO:0000269PubMed:8021504}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR008677
MRVI1
|
PFAM |
PF05781
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q12912
|
PhosphoSite |
PhosphoSite-Q12912
|
TrEMBL |
G3V513
|
UniProt Splice Variant |
|
Entrez Gene |
4033
|
UniGene |
Hs.124922
|
RefSeq |
NP_006143
|
HUGO |
HGNC:6690
|
OMIM |
602003
|
CCDS |
CCDS8701
|
HPRD |
03593
|
IMGT |
|
EMBL |
AC023510
AK303256
BC029391
BC126417
U10485
|
GenPept |
AAA21604
AAH29391
AAI26418
BAG64339
|
|
|