Version 5.4
Homo sapiens Protein: GLDN
Summary
InnateDB Protein IDBP-237600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLDN
Protein Name gliomedin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379681
InnateDB Gene IDBG-12060 (GLDN)
Protein Structure
UniProt Annotation
Function Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Single-pass type II membrane protein. Note=Localizes to the nodes of Ranvier. {ECO:0000250}.
Disease Associations
Tissue Specificity Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system. {ECO:0000269PubMed:16039564}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005581 collagen trimer
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003112 Olfactomedin-like
IPR008160 Collagen triple helix repeat
PFAM PF02191
PF01391
PRINTS
PIRSF
SMART SM00284
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZMI3
PhosphoSite PhosphoSite-Q6ZMI3
TrEMBL
UniProt Splice Variant
Entrez Gene 342035
UniGene Hs.708512
RefSeq XP_006720545
HUGO HGNC:29514
OMIM 608603
CCDS
HPRD 12267
IMGT
EMBL AK172756 AY358144 BK001262 BX538105
GenPept AAQ88511 BAD18742 CAD98018 DAA01143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca