InnateDB Protein
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IDBP-23776.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHLDA2
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Protein Name
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pleckstrin homology-like domain, family A, member 2
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Synonyms
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BRW1C; BWR1C; HLDA2; IPL; TSSC3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000319231
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InnateDB Gene
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IDBG-23772 (PHLDA2)
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Protein Structure
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Function |
Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines. {ECO:0000269PubMed:10594239, ECO:0000269PubMed:10749982, ECO:0000269PubMed:13129680, ECO:0000269PubMed:15457853, ECO:0000269PubMed:9328465}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q53GA4
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PhosphoSite |
PhosphoSite-Q53GA4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7262
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UniGene |
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RefSeq |
NP_003302
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HUGO |
HGNC:12385
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OMIM |
602131
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CCDS |
CCDS7741
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HPRD |
03679
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IMGT |
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EMBL |
AF001294
AF019953
AF035444
AK223027
BC005034
CR407664
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GenPept |
AAB86680
AAC17458
AAC51912
AAH05034
BAD96747
CAG28592
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