InnateDB Protein
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IDBP-23793.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD19
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Protein Name
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CD19 molecule
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Synonyms
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B4; CVID3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000313419
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InnateDB Gene
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IDBG-23791 (CD19)
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Protein Structure
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Function |
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269PubMed:16672701}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
P15391
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PhosphoSite |
PhosphoSite-P15391
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TrEMBL |
Q71UW0
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UniProt Splice Variant |
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Entrez Gene |
930
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UniGene |
Hs.652262
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RefSeq |
NP_001761
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HUGO |
HGNC:1633
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OMIM |
107265
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CCDS |
CCDS10644
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HPRD |
00113
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IMGT |
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EMBL |
AB052799
AC109460
AF045018
AK313577
BC006338
CH471267
EF064757
M21097
M28170
M62544
M62545
M62546
M62547
M62548
M62549
M62550
M84371
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GenPept |
AAA35533
AAA68490
AAA69966
AAB60697
AAD02340
AAH06338
ABK41940
BAB60954
EAW52012
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