Version 5.4
Homo sapiens Protein: CCP110
Summary
InnateDB Protein IDBP-237973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCP110
Protein Name centriolar coiled coil protein 110kDa
Synonyms Cep110; CP110;
Species Homo sapiens
Ensembl Protein ENSP00000379511
InnateDB Gene IDBG-17857 (CCP110)
Protein Structure
UniProt Annotation
Function Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. {ECO:0000269PubMed:12361598, ECO:0000269PubMed:16760425, ECO:0000269PubMed:17681131, ECO:0000269PubMed:17719545, ECO:0000269PubMed:23486064}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:12361598, ECO:0000269PubMed:14654843, ECO:0000269PubMed:16760425, ECO:0000269PubMed:17681131, ECO:0000269PubMed:17719545, ECO:0000269PubMed:20596027, ECO:0000269PubMed:21620453}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.
Disease Associations
Tissue Specificity Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:12361598}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007099 centriole replication
GO:0030030 cell projection organization
GO:0032465 regulation of cytokinesis
GO:0051298 centrosome duplication
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43303
PhosphoSite PhosphoSite-O43303
TrEMBL
UniProt Splice Variant
Entrez Gene 9738
UniGene Hs.606159
RefSeq XP_006721168
HUGO HGNC:24342
OMIM 609544
CCDS CCDS10579
HPRD 10848
IMGT
EMBL AB007879 AC003108 AC012621 BC036654 CR749255
GenPept AAC05804 AAH36654 BAA24849 CAH18111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca