InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDA2R

Summary

InnateDB Protein

IDBP-238312.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDA2R

Protein Name

ectodysplasin A2 receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379365

InnateDB Gene

IDBG-73673 (EDA2R)

Protein Structure

UniProt Annotation

Function

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269PubMed:12270937}.

Subcellular Localization

Membrane; Single-pass type III membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0008544	epidermis development
GO:0009790	embryo development
GO:0030154	cell differentiation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0046330	positive regulation of JNK cascade
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator