Version 5.4
Homo sapiens Protein: ST8SIA1
Summary
InnateDB Protein IDBP-238338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST8SIA1
Protein Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Synonyms GD3S; SIAT8; SIAT8-A; SIAT8A; ST8SiaI;
Species Homo sapiens
Ensembl Protein ENSP00000379353
InnateDB Gene IDBG-23371 (ST8SIA1)
Protein Structure
UniProt Annotation
Function Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. {ECO:0000269PubMed:7937974, ECO:0000269PubMed:8058740, ECO:0000269PubMed:8195250, ECO:0000269PubMed:8631981}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung. {ECO:0000269PubMed:7937974, ECO:0000269PubMed:8631981}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0006688 glycosphingolipid biosynthetic process
GO:0008284 positive regulation of cell proliferation
GO:0034605 cellular response to heat
GO:0097503 sialylation
Cellular Component
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92185
PhosphoSite PhosphoSite-Q92185
TrEMBL H0YFU1
UniProt Splice Variant
Entrez Gene 6489
UniGene Hs.740059
RefSeq NP_003025
HUGO HGNC:10869
OMIM 601123
CCDS CCDS8697
HPRD 03078
IMGT
EMBL AC007544 AC007671 AC053513 AC087318 AC138468 AK290941 AK315340 AY569975 BC117285 BC126162 CH471094 D26360 EU041716 L32867 L43494 X77922
GenPept AAA62366 AAC37586 AAI17286 AAI26163 AAS75783 ABU62753 BAA05391 BAF83630 BAG37739 CAA54891 EAW96468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca