InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BDNF

Summary

InnateDB Protein

IDBP-238444.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BDNF

Protein Name

brain-derived neurotrophic factor

Synonyms

ANON2; BULN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000379307

InnateDB Gene

IDBG-36817 (BDNF)

Protein Structure

UniProt Annotation

Function

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269PubMed:12553913}.

Subcellular Localization

Secreted.

Disease Associations

Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. {ECO:0000269PubMed:11840487}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. {ECO:0000269PubMed:17629449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007399	nervous system development
GO:0051965	positive regulation of synapse assembly

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002072 Nerve growth factor-related
IPR020408 Nerve growth factor-like
IPR020430 Brain-derived neurotrophic factor
IPR029034 Cystine-knot cytokine

PFAM

PF00243

PRINTS

PR00268
PR01912

PIRSF

PIRSF001789

SMART

SM00140

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P23560

PhosphoSite

PhosphoSite-P23560

TrEMBL

S5MI63

UniProt Splice Variant

Entrez Gene

627

UniGene

Hs.678259

RefSeq

NP_001137281

HUGO

HGNC:1033

OMIM

113505

CCDS

CCDS7866

HPRD

00214

IMGT

EMBL

AB038670 AB038671 AB038672 AB038673 AB038674 AC104563 AF400438 AF411339 AK289763 AK289853 AY011481 AY054392 AY054393 AY054394 AY054395 AY054396 AY054397 AY054398 AY054399 AY054400 AY656701 BC029795 CH471064 EF674517 EF674518 EF674519 EF674520 EF674521 EF689009 EF689010 EF689011 EF689012 EF689013 EF689014 EF689015 EF689016 EF689017 EF689018 EF689019 EF689020 EF689021 KC855559 M37762 M61176 M61181 X60201 X91251

GenPept

AAA51820 AAA69805 AAA96140 AAG47514 AAH29795 AAK92487 AAL23557 AAL23558 AAL23559 AAL23560 AAL23561 AAL23562 AAL23563 AAL23564 AAL23565 AAO15434 AAT74399 ABS29021 ABS29022 ABS29023 ABS29024 ABS29025 ABS32249 ABS32250 ABS32251 ABS32252 ABS32253 ABS32254 ABS32255 ABS32256 ABS32257 ABS32258 ABS32259 ABS32260 ABS32261 AGR50950 BAB55545 BAB55546 BAB55547 BAB55548 BAB55549 BAF82452 BAF82542 CAA42761 CAA62632 EAW68274 EAW68275 EAW68276 EAW68277 EAW68278 EAW68279